Preferred Label : C57BL/10 Mouse;
NCIt synonyms : C57BL 10 Mouse;
NCIt related terms : C57BL/10;
NCIt definition : Derived by Little (1921) from A Lathrop stocks and separated out before 1937. The
C57BL/10 strain carries a Y chromosome of Asian Mus musculus origin and a LINE-1 element
from Mus spretus, suggesting that up to 6.5% of the genome is Mus spretus in origin.
Substrain C57BL/10 differs from other substrains at multiple loci, including H9, Igh2
and Lv, on chromosome 4 and has a high incidence of spontaneous mutations. The mouse
model has a 30% spontaneous tumor formation in both sexes, these tumors are comprised
mostly of lymphomas. The C57BL/10 strain exhibits good reproductive performance.;
Alternative definition : CDISC: Derived by Little (1921) from A Lathrop stocks and separated out before 1937,
the C57BL/10 mouse has a black coat and carries a Y chromosome of Asian Mus musculus
origin and a LINE-1 element from Mus spretus. Substrain C57BL/10 differs from other
substrains at multiple loci, including H9, Igh2 and Lv, on chromosome 4 and has a
high incidence of spontaneous mutations.;
Origin ID : C37376;
UMLS CUI : C1511377;
Semantic type(s)
- concept_is_in_subset
