ZBTB16-RARA Fusion Protein Expression

Preferred Label : ZBTB16-RARA Fusion Protein Expression;

NCIt synonyms : PLZF-RARalpha Fusion Protein Expression; ZBTB16/RARA Fusion Protein Expression; PLZF/RARA Fusion Protein Expression;

NCIt definition : A fusion protein encoded by a t(15;17) translocation, which involves the human genes ZBTB16 and RARA and is characteristic of acute promyelocytic leukemia. It is a transcriptional repressor with both gain-of-function and dominant-negative properties, resulting in transcriptional repression of retinoic acid and non-retinoic acid target genes and culminating in differentiation arrest.;

Details

Origin ID

C37220;

UMLS CUI

C1518796;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
molecular_abnormality_involves_gene
- RARA Gene [NCIt concept]
- ZBTB16 Gene [NCIt concept]
- ZBTB16/RARA Fusion Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients