Preferred Label : Chlormadinone Acetate;
NCIt synonyms : Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro-; Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-, acetate; CMA;
NCIt related terms : 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione;
NCIt definition : The actetate salt form of chlormadinone, a synthetic progestin with antiandrogenic
and antigonadotropic effects. Chlormadinone acetate (CMA) is a potent progesterone
receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid
receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression
of progesterone-responsive genes. In addition, chlormadinone blocks ARs in target
organs and reduces the activity of skin 5 alpha-reductase; thus inhibiting androgen
production and signaling. Through the negative feedback action on the hypothalamus-pituitary
system, chlormadinone also suppresses gonadotropin secretion, which prevents ovarian
and adrenal androgen production. Therefore, this agent decreases endometrial thickness,
increases the viscosity of cervical mucus, inhibits ovulation and suppresses follicular
growth and maturation.;
UNII : 0SY050L61N;
InChIKey : QMBJSIBWORFWQT-DFXBJWIESA-N;
CAS number : 302-22-7;
Chemical formula : C23H29ClO4;
NSC code : 92338;
Codes from synonyms : 00944;
Origin ID : C365;
UMLS CUI : C0008214;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
