t(11;17)(q13;q21)

Preferred Label : t(11;17)(q13;q21);

NCIt synonyms : t 11 17 q13 q21;

NCIt definition : A chromosomal translocation involving breakpoints within the q13 band on the long arm of chromosome 11 and the q21 band on the long arm of chromosome 17. This translocation may be associated with NUMA1-RARA fusion gene expression and acute promyelocytic leukemia or with the expression of various fusion genes (including FCHSD2-THRA, MBTD1-MYO7A, RNF169-CALCOCO2, RNF169-CBX1 and TPCN2-RARA) and solid tumors.;

Details

Origin ID

C36364;

UMLS CUI

C1515706;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 11 [NCIt concept]
- Human Chromosome 17 [NCIt concept]
is_abnormality_of_gene
- NUMA1/RARA Fusion Gene [NCIt concept]
molecular_abnormality_involves_gene
- NUMA1 Gene [NCIt concept]
- NUMA1/RARA Fusion Gene [NCIt concept]
- RARA Gene [NCIt concept]
related_to_genetic_biomarker
- CALCOCO2 Gene [NCIt concept]
- CBX1 Gene [NCIt concept]
- FCHSD2 Gene [NCIt concept]
- MBTD1 Gene [NCIt concept]
- MYO7A Gene [NCIt concept]
- RNF169 Gene [NCIt concept]
- THRA Gene [NCIt concept]
- TPCN2 Gene [NCIt concept]

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