Clonal Gene Rearrangement

Preferred Label : Clonal Gene Rearrangement;

NCIt synonyms : Monoclonal Gene Rearrangement;

NCIt definition : A DNA sequence rearrangement that results in the creation of novel immunoglobulins and T-cell receptors expressed by lymphocytes. This process occurs very early in the differentiation of B- and T-lymphocytes, such that individual B- and T-cell progenitors have unique genetic profiles that are passed down to their descendants. This leads to clonal populations of lymphocytes expressing the unique proteins selected during maturation.;

Details

Origin ID

C36333;

UMLS CUI

C0443976;

Currated CISMeF NLP mapping
- Monoclonal gene rearrangement (substance) [SNOMED CT concept]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- Monoclonal gene rearrangement (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
is_not_molecular_abnormality_of_disease
- Acute Lymphadenitis [NCIt concept]
- Axillary Lymphadenitis [NCIt concept]
- Benign Lymphoproliferative Disorder [NCIt concept]
- Cervical Lymphadenitis [NCIt concept]
- Chronic Lymphadenitis [NCIt concept]
- Chronic Lymphoproliferative Disorder of NK-Cells [NCIt concept]
- Cutaneous Pseudolymphoma [NCIt concept]
- Follicular Bronchitis/Bronchiolitis [NCIt concept]
- Infectious Mononucleosis [NCIt concept]
- Kikuchi-Fujimoto Disease [NCIt concept]
- Lymphadenitis [NCIt concept]
- Mesenteric Lymphadenitis [NCIt concept]
- Nodular Lymphoid Hyperplasia of Lung [NCIt concept]
- Postauricular Lymphadenitis [NCIt concept]
- Reactive B-Cell Rich Lymphoid Proliferations that Can Mimic Lymphoma [NCIt concept]
- Submandibular Lymphadenitis [NCIt concept]
- Suppurative Lymphadenitis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients