Acute Adult T-Cell Leukemia/Lymphoma

Preferred Label : Acute Adult T-Cell Leukemia/Lymphoma;

NCIt synonyms : Acute Adult T-Cell Lymphoma/Leukemia; Acute Adult T-Cell Lymphoma Leukemia;

NCIt definition : The most common variant of adult T-cell leukemia/lymphoma. It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions. Hypercalcemia is commonly seen.;

Neoplastic status : Malignant;

Details

Origin ID

C36265;

UMLS CUI

C1332146;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor Natural Killer Cell [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Elevated LDH [NCIt concept]
- Eosinophilia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lytic Metastatic Bone Lesion [NCIt concept]
- Splenomegaly [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_associated_disease
- HTLV-1 Infection [NCIt concept]
- Infectious Disorder [NCIt concept]
- Viral Infection [NCIt concept]
disease_has_associated_gene
- OLIG2 Gene [NCIt concept]
- OLIG2 wt Allele [NCIt concept]
disease_has_finding
- Adulthood Lesion [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Peripheral Blood Involvement [NCIt concept]
disease_has_molecular_abnormality
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- CD4-Positive T-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Neoplastic Medium-Sized T-Lymphocyte [NCIt concept]
- Pleomorphic Medium-Sized to Large T-Lymphocyte [NCIt concept]
- Pleomorphic Small T-Lymphocyte [NCIt concept]
- Polylobated T-Lymphocyte [NCIt concept]

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