Non-Hereditary Clear Cell Renal Cell Carcinoma

Preferred Label : Non-Hereditary Clear Cell Renal Cell Carcinoma;

NCIt synonyms : Sporadic Conventional (Clear Cell) Renal Cell Carcinoma; Non-Hereditary Conventional (Clear Cell) Renal Cell Carcinoma; Sporadic Clear Cell Renal Cell Carcinoma; Non-Hereditary Conventional Clear Cell Renal Cell Carcinoma;

NCIt definition : The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3. The most common symptom at the time of diagnosis is hematuria. The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid. This is a clinically aggressive type of renal cell carcinoma. The tumor usually metastasizes to unusual sites and late metastasis is common.;

Neoplastic status : Malignant;

Details

Origin ID

C36261;

UMLS CUI

C1334978;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Bilateral Disease [NCIt concept]
- Calcification [NCIt concept]
- Cystic Change [NCIt concept]
- Flank Pain [NCIt concept]
- Hematuria [NCIt concept]
- Necrotic Change [NCIt concept]
Has associated anatomic sites
- Genitourinary System [NCIt concept]
- Kidney [NCIt concept]
- Kidney and Ureter [NCIt concept]
- Urinary System [NCIt concept]
Has cytogenetic abnormalities
- Loss of Chromosome 3 [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Adenocarcinoma Clear Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Delicate Vascular Network Formation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Non-Hereditary Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Renal Tubular Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Renal Tubule Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Genitourinary System [NCIt concept]
- Kidney [NCIt concept]
- Renal Tubule [NCIt concept]
- Urinary System [NCIt concept]
disease_may_have_molecular_abnormality
- EGFR Gene Amplification [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]
- VHL Gene Inactivation [NCIt concept]

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