" /> Diffuse Large B-Cell Lymphoma Activated B-Cell Type - CISMeF





Preferred Label : Diffuse Large B-Cell Lymphoma Activated B-Cell Type;

NCIt synonyms : Diffuse Large B-Cell Lymphoma with an Activated B-Cell Expression Profile; ABC-DLBCL; ABC DLBCL; Activated B-Cell-Like Diffuse Large B-Cell Lymphoma; DLBCL Activated B-Cell Type; Non-GC/ABC DLBCL; Diffuse Large B-Cell Lymphoma Non-Germinal Center/Activated B-Cell Type; Diffuse Large B-Cell Lymphoma Non-GC/ABC;

NCIt definition : A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. It represents approximately 30% of diffuse large B-cell lymphomas, and is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes. Morphologically, these lymphomas are either centroblastic or immunoblastic (ratio 2:1). Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome compared to those with a germinal center B-cell expression profile, with a 5-year survival rate of 35% and a median survival of 2 years.;

Neoplastic status : Malignant;

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04/05/2024


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