Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type - CISMeF
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeNCIt concept
Preferred Label : Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type;
NCIt synonyms : Diffuse Large B-Cell Lymphoma with a Germinal Center B-Cell Expression Profile; GCB-DLBCL; DLBCL Germinal Center B-Cell Type; Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma;
NCIt definition : A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature
or expression profile. It represents approximately 50% of diffuse large B-cell lymphomas,
and is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2
translocation, and c-REL amplification. Morphologically, the vast majority of these
lymphomas are centroblastic and a small minority are immunoblastic (ratio20:1). Patients
with this type of diffuse large B-cell lymphoma have a more favorable outcome, with
a 5-year survival rate of 60% and a median survival of 10 years.;