Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Preferred Label : Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type;

NCIt synonyms : Diffuse Large B-Cell Lymphoma with a Germinal Center B-Cell Expression Profile; GCB-DLBCL; DLBCL Germinal Center B-Cell Type; Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma;

NCIt definition : A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. It represents approximately 50% of diffuse large B-cell lymphomas, and is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification. Morphologically, the vast majority of these lymphomas are centroblastic and a small minority are immunoblastic (ratio20:1). Patients with this type of diffuse large B-cell lymphoma have a more favorable outcome, with a 5-year survival rate of 60% and a median survival of 10 years.;

Neoplastic status : Malignant;

Details

Origin ID

C36080;

UMLS CUI

C1333295;

Automatic exact mappings (from CISMeF team)
- diffuse large B-cell lymphoma germinal center B-cell type [DO Concept]
Currated CISMeF NLP mapping
- germinal center like diffuse large B cell lymphoma [Disease (Nov.)]
Disease excludes abnormal cell
- Lymphocyte Predominant Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Plasmablastic Immunoblast [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
- Thymic B-Lymphocyte [NCIt concept]
Disease may have findings
- Favorable Clinical Outcome [NCIt concept]
- Lymphadenopathy [NCIt concept]
Excludes anatomical site(s)
- Thymus Gland [NCIt concept]
- Vascular System [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- germinal center like diffuse large B cell lymphoma [Disease (Nov.)]
concept_is_in_subset
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Histiocytosis [NCIt concept]
disease_excludes_molecular_abnormality
- ALK Kinase Overexpression [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Large B-Lymphocyte [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Diffuse Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_has_molecular_abnormality
- A-myb Messenger RNA Overexpression [NCIt concept]
- BCL-6 Messenger RNA Overexpression [NCIt concept]
- BCL2 Gene Translocation [NCIt concept]
- CD10 Messenger RNA Overexpression [NCIt concept]
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- LMO2 Messenger RNA Overexpression [NCIt concept]
- REL Gene Amplification [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Germinal Center B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]

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