Acute Promyelocytic Leukemia with a Variant RARA Rearrangement

Preferred Label : Acute Promyelocytic Leukemia with a Variant RARA Rearrangement;

NCIt synonyms : Acute Promyelocytic Leukemia with Variant Translocations; Acute Promyelocytic Leukemia with Other RARA Rearrangements; Acute Myeloid Leukemia with a Variant RARA Rearrangement;

NCIt related terms : AML with Variant RARA Translocation; Acute Myeloid Leukemia with a Variant RARA Translocation;

NCIt definition : A term that refers to acute promyelocytic leukemias that show variant translocations involving the RARA gene. The variant fusion partners include NUMA1, ZBTB16, STAT5B, and NPM1.;

Alternative definition : NICHD: A term referring to acute myeloid leukemias which show variant translocations involving the RARA gene. The variant fusion partners include NUMA1, ZBTB16 (PLZF), STAT5B, and NPM1. These leukemias often have the morphologic features of acute promyelocytic leukemia.;

Neoplastic status : Malignant;

Détails

Origin ID

C36055;

UMLS CUI

C2825128;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- RARA Gene Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- t(15;17)(q24;q21) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- PML-RARA Fusion Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neoplastic Promyelocyte [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Promyelocytes in Bone Marrow Markedly Increased [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- RARA Gene [NCIt concept]
disease_may_have_abnormal_cell
- Faggot Cell [NCIt concept]
disease_may_have_associated_disease
- Disseminated Intravascular Coagulation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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