NCIt definition : An uncommon neurovascular condition seen with exertion of the upper extremity. It
is usually caused by atherosclerotic stenosis or occlusion of the subclavian artery
proximal to the origin of the vertebral artery. In order to maintain adequate perfusion
of the arm during exercise on the affected side, the narrowed subclavian artery siphons
off retrograde blood flow from the ipsilateral vertebral artery. This is possible
due to lower blood pressure distal to the site of narrowing and collateral circulation
through the circle of Willis. Affected individuals may remain asymptomatic until the
oxygen demand generated from upper extremity exercise requires a large enough compensatory
volume of blood to be diverted from the vertebral artery to provoke vertebrobasilar
insufficiency and its accompanying neurological sequelae. Presenting clinical signs
may include pain or numbness of the affected arm (with diminished pulses and a brachial
systolic blood pressure differential of greater than 20 mmHg as compared to the opposite
arm), vertigo, tinnitus, dysarthria, diplopia and syncope. Notably, unlike cerebral
infarction, the clinical course does not lead to chronic neurologic disability. Prognosis
for recovery of normal anterograde circulation is favorable following endovascular
or surgical intervention.;