NCIt definition : An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus
(GABHS), in which the heart is attacked by antibodies formed in reaction to a recent
GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural
fusion, and shortening and thickening of the tendinous cords, all of which can result
in valvular dysfunction.;
Alternative definition : NICHD: A consequence of acute rheumatic fever that causes chronic cardiac valve damage
and/or dysfunction.;