Carboquone - CISMeF

Preferred Label : Carboquone;

NCIt definition : An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in carboquone becomes activated upon reduction of quinone to the hydroquinone form. This eventually results in the alkylation and crosslinking of DNA, thereby inhibiting DNA replication followed by an induction of apoptosis. In addition, reactive oxygen species may form during redox cycling which may contribute to this agent's cytotoxic activity.;

UNII : 1CB0HBT12C;

InChIKey : SHHKQEUPHAENFK-UHFFFAOYSA-N;

CAS number : 24279-91-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 24279-91-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C15H19N3O5;

NSC code : 662;

Codes from synonyms : NSC0000662;

Details

Origin ID

C342;

UMLS CUI

C0006971;

Automatic exact mappings (from CISMeF team)
- Carboquone [ICHI extension code]
Currated CISMeF NLP mapping
- Carboquone [ICD-11 Extension code]
- carbazilquinone [MeSH Descriptor]
- carbazilquinone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Carboquone [ICD-11 Extension code]
- carbazilquinone [MeSH concept]
- carbazilquinone [MeSH Descriptor]
- carboquone [ATC Code]
Validated automatic mappings to BTNT
- carboquone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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