NCIt definition : A cell of the interstitial tissue of the renal parenchyma. A renal interstitial cell
is one of two types. A type I interstitial cell is a fibroblastic cell that is active
in the deposition and degradation of the interstitial matrix. It contributes to fibrosis
in response to chronic irritation. A type II cell is a macrophage-derived mononuclear
cell with phagocytic and immunologic properties. A type II cell is important in antigen
presentation. Its cytokines contribute to recruitment of infiltrating cells, progression
of injury, and sustenance of fibrogenesis.;