Preferred Label : Calcitriol;
NCIt synonyms : 1,25-Dihydroxycholecalciferol; (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1,25(OH)2-D3; 1,25-DHCC; 1,25-Dihydroxycholecaliferol;
NCIt definition : A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3
form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine,
reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone
growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human
intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle,
cell differentiation, and apoptosis, resulting in inhibition of proliferation of some
tumor cell types. This agent may be chemopreventive for colon and prostate cancers.
(NCI04);
Alternative definition : NCI-GLOSS: The active form of vitamin D. Calcitriol is formed in the kidneys or made
in the laboratory. It is used as a drug to increase calcium levels in the body in
order to treat skeletal and tissue-related calcium deficiencies caused by kidney or
thyroid disorders.;
UNII : FXC9231JVH;
InChIKey : GMRQFYUYWCNGIN-NKMMMXOESA-N;
CAS number : 32222-06-3;
Drug name : Rocaltrol; Calcijex;
Chemical formula : C27H44O3;
ChEBI ID : CHEBI:17823;
Codes from synonyms : CDR0000045408; 00075;
Origin ID : C330;
UMLS CUI : C0006674;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
