NCIt synonyms : CA125; Cancer Antigen 125; Carbohydrate Antigen 125;
NCIt related terms : CA-125;
NCIt definition : An antigen expressed by tissues derived from mullerian epithelium (tubal, endometrial
and endocervical) or celomic epithelium (mesothelial cells of the pleura, pericardium
and peritoneum). Although its biochemical nature has not been clearly defined, CA125
has been described as a glycosylated, high-molecular-weight protein that may be released
from damaged cells. Measurable in plasma, CA125 is a sensitive, nonspecific tumor
marker for ovarian cancer; as such it is much more useful for monitoring clinical
responses to the treatment of ovarian cancer than for the diagnosis of ovarian cancer.
Elevated plasma CA125 may occur in association with other malignancies and non-malignant
gynecologic disorders. (NCI04);
Alternative definition : NCI-GLOSS: A substance that may be found in high amounts in the blood of patients
with certain types of cancer, including ovarian cancer. CA-125 levels may also help
monitor how well cancer treatments are working or if cancer has come back.;
UNII : 45047SF2ZS;
Codes from synonyms : CDR0000046490; CDR0000579637;
Semantic type(s)