NCIt related terms : chronic phase chronic myelogenous leukemia;
NCIt definition : A phase of chronic myeloid leukemia, BCR-ABL1 positive in which the peripheral blood
smear shows leukocytosis with neutrophils in different stages of maturation, less
than 2% blasts, and normal or increased platelet count. Most patients have mild anemia.
The bone marrow is hypercellular due to increased numbers of neutrophils and their
precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes
are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to
infiltration of the cords of the red pulp by granulocytes.;
Alternative definition : NCI-GLOSS: A phase of chronic myelogenous leukemia in which fewer than 10% of the
cells in the blood and bone marrow are blast cells (immature blood cells). This phase
may last from several months to several years, and there may be no symptoms of leukemia.;