Preferred Label : Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive;
NCIt synonyms : Aggressive-Phase Chronic Myelocytic Leukemia; Accelerated Phase Chronic Myeloid Leukemia; Aggressive-Phase Chronic Myelogenous Leukemia; Accelerated Phase Chronic Myelogenous Leukemia; Accelerated Phase Chronic Myelocytic Leukemia; Accelerated Phase CML; Aggressive-Phase CML; Aggressive-Phase Chronic Myeloid Leukemia; Accelerated Phase Chronic Granulocytic Leukemia; Accelerated Phase Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Accelerated Phase Chronic Myeloid Leukemia, BCR::ABL1 Positive;
NCIt definition : A phase of chronic myeloid leukemia characterized by one or more of the following:
1) Myeloblasts accounting for 10-19% of the peripheral blood white cells or of the
nucleated cells in the bone marrow, 2) peripheral blood basophils at least 20%, 3)
persistent thrombocytopenia that is unrelated to therapy, 4) persistent thrombocytosis
despite adequate therapy, 5) increasing white blood cell count and increasing spleen
size unresponsive to therapy, and/or evidence of clonal evolution. (WHO, 2001);
Alternative definition : NCI-GLOSS: A phase of chronic myelogenous leukemia in which the disease is progressing.
In this phase, 10% to 19% of the cells in the blood and bone marrow are blast cells
(immature blood cells).;
Neoplastic status : Malignant;
Codes from synonyms : CDR0000046212;
Origin ID : C3173;
UMLS CUI : C0023472;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Disease excludes normal cell origin
- Disease may have findings
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- disease_excludes_finding
- disease_excludes_molecular_abnormality
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_molecular_abnormality
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_mapped_to_gene
- disease_may_have_associated_disease
- disease_may_have_cytogenetic_abnormality
