Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

Preferred Label : Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive;

NCIt synonyms : Aggressive-Phase Chronic Myelocytic Leukemia; Accelerated Phase Chronic Myeloid Leukemia; Aggressive-Phase Chronic Myelogenous Leukemia; Accelerated Phase Chronic Myelogenous Leukemia; Accelerated Phase Chronic Myelocytic Leukemia; Accelerated Phase CML; Aggressive-Phase CML; Aggressive-Phase Chronic Myeloid Leukemia; Accelerated Phase Chronic Granulocytic Leukemia; Accelerated Phase Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Accelerated Phase Chronic Myeloid Leukemia, BCR::ABL1 Positive;

NCIt definition : A phase of chronic myeloid leukemia characterized by one or more of the following: 1) Myeloblasts accounting for 10-19% of the peripheral blood white cells or of the nucleated cells in the bone marrow, 2) peripheral blood basophils at least 20%, 3) persistent thrombocytopenia that is unrelated to therapy, 4) persistent thrombocytosis despite adequate therapy, 5) increasing white blood cell count and increasing spleen size unresponsive to therapy, and/or evidence of clonal evolution. (WHO, 2001);

Alternative definition : NCI-GLOSS: A phase of chronic myelogenous leukemia in which the disease is progressing. In this phase, 10% to 19% of the cells in the blood and bone marrow are blast cells (immature blood cells).;

Neoplastic status : Malignant;

Codes from synonyms : CDR0000046212;

Details

Origin ID

C3173;

UMLS CUI

C0023472;

Automatic exact mappings (from CISMeF team)
- leukemia, myeloid, accelerated phase [MeSH concept]
Currated CISMeF NLP mapping
- Accelerated phase chronic myeloid leukemia (disorder) [SNOMED CT concept]
- leukemia, myeloid, accelerated phase [MeSH Descriptor]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Basophilia [NCIt concept]
- Blasts 10-19 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10-19 Percent of Peripheral Blood White Cells [NCIt concept]
- Fatigue [NCIt concept]
- Hepatomegaly [NCIt concept]
- Leukocytosis [NCIt concept]
- Myeloblasts 10-19 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Myeloblasts 10-19 Percent of Peripheral Blood White Cells [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Thrombocytosis [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Accelerated phase chronic myeloid leukemia (disorder) [SNOMED CT concept]
- accelerated phase of chronic myeloid leukemia [Disease (Nov.)]
- leukemia, myeloid, accelerated phase [MeSH Descriptor]
- leukemia, myeloid, accelerated phase [MeSH concept]
Validated automatic mappings to NTBT
- accelerated phase of chronic myeloid leukemia [Disease (Nov.)]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- FGFR1 Gene Rearrangement [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Accelerated Phase of Disease [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Splenomegaly [NCIt concept]
disease_has_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome Y [NCIt concept]
- Monosomy 7 [NCIt concept]
- Trisomy 8 [NCIt concept]
- i(17q) [NCIt concept]
- i(19) [NCIt concept]

Keyword's position in hierarchy(ies) :

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