Bromocriptine Mesylate

Preferred Label : Bromocriptine Mesylate;

NCIt synonyms : Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, monomethanesulfonate (salt), (5'alpha)-; Bromocriptine;

NCIt related terms : 2-Bromo-alpha-ergocryptine Mesylate;

NCIt definition : The mesylate salt of bromocriptine, a semisynthetic ergot alkaloid with dopaminergic, antidyskinetic, and antiprolactinemic activities. Bromocriptine selectively binds to and activates postsynaptic dopamine D2 receptors in the corpus striatum of the central nervous system (CNS). Activation of these D2 receptors activate inhibitory G-proteins, which inhibit adenylyl cyclase, preventing signal transduction mediated via cAMP and resulting in the inhibition of neurotransmission and an antidyskinetic effect. This agent also stimulates dopamine D2 receptors in the anterior pituitary gland, which results in the inhibition of prolactin secretion and lactation and may inhibit the proliferation of prolactin-dependent breast cancer cells.;

UNII : FFP983J3OD;

InChIKey : NOJMTMIRQRDZMT-GSPXQYRGSA-N;

CAS number : 22260-51-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 22260-51-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Parlodel;

Chemical formula : C32H40BrN5O5.CH4O3S;

ChEBI ID : CHEBI:3182;

Codes from synonyms : 05719;

Details

Origin ID

C317;

UMLS CUI

C0546852;

Automatic exact mappings (from CISMeF team)
- Bromocriptine [ICHI extension code]
- bromocriptine [ATC Code]
- bromocriptine [ATC Code]
See also inter- (CISMeF)
- Product containing bromocriptine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-Bromoergocryptine Mesylate [MeSH concept]
- 2-bromo-12'-hydroxy-5'.alpha.-isobutyl-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate [Substance BNPC]
- Bromocriptine mesilate (substance) [SNOMED CT concept]
- bromocriptine mesylate [International Nonproprietary Name]
- bromocriptine mesylate [SNOMED Notion]
Validated automatic mappings to NTBT
- Bromocriptine [LOINC component]
- Bromocriptine [ICD-11 Extension code]
- Bromocriptine (substance) [SNOMED CT concept]
- bromocriptine [Substance BNPC]
- bromocriptine [MeSH concept]
- bromocriptine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Bromocriptine [NCIt concept]
is_component_of_chemotherapy_regimen
- Bromocriptine/Flutamide [NCIt concept]
- Bromocriptine/Flutamide/Leuprolide [NCIt concept]
is_salt_form_of
- Bromocriptine [NCIt concept]

Keyword's position in hierarchy(ies) :

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