NCIt definition : A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous
cells. It usually occurs on sun-exposed areas of the body, most often the head, neck,
and limbs. It is considered a variant of well-differentiated squamous cell carcinoma
with distinct clinical behavior. Keratoacanthomas affect males more frequently than
females and the majority tend to regress spontaneously.;
Alternative definition : NCI-GLOSS: A rapidly growing, dome-shaped skin tumor that usually occurs on sun-exposed
areas of the body, especially around the head and neck. Keratoacanthoma occurs more
often in males. Although in most patients it goes away on its own, in a few patients
it comes back. Rarely, it may spread to other parts of the body.;