Preferred Label : Type I Hypersensitivity;
NCIt synonyms : Immediate Hypersensitivity; Type I Hypersensitivity Reaction;
NCIt related terms : Type 1 Hypersensitivity; Type I Immediate Hypersensitivity Reaction; Type 1 Hypersensitivity Reaction;
NCIt definition : Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated
release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4
and IL-13, which then act on B cells to promote the production of antigen-specific
IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking
the bound IgE antibodies on the mast cells and basophils. This causes the release
of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly
synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating
factor, adenosine, bradykinin), and cytokines from these cells that results in structural
and functional changes to the affected tissue.;
Alternative definition : NICHD: An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually
occur within an hour of exposure to an allergen.;
Origin ID : C3116;
UMLS CUI : C0020523;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
