Bleomycin A2 - CISMeF

Preferred Label : Bleomycin A2;

NCIt synonyms : Zhengguangmycin A2; Pingyangmycin A2; N1-(3-(Dimethylsulfonio)propyl)bleomycinamide;

NCIt definition : The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin A2 forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04);

UNII : 13M89UEA7W;

InChIKey : OYVAGSVQBOHSSS-UAPAGMARSA-N;

CAS number : 11116-31-7;

Chemical formula : C55H84N17O21S3;

NSC code : 146842;

ChEBI ID : CHEBI:3139;

Codes from synonyms : NSC0146842;

Details

Origin ID

C311;

UMLS CUI

C0005736;

Currated CISMeF NLP mapping
- bleomycin A2 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- bleomycin A2 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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