NCIt synonyms : Gynandroblastoma of the Ovary; Gynandroblastoma of Ovary;
NCIt related terms : Gynandroblastoma;
NCIt definition : A rare neoplasm arising from the ovary. Although it may occur at any age, it is more
often seen in young females. Morphologically, it is characterized by a mixture of
two cellular populations: well differentiated Sertoli cells and granulosa cells, with
the latter constituting at least ten percent of the neoplasm. The vast majority of
cases are stage I lesions at presentation and produce either estrogenic or androgenic
manifestations. Although it may present as a massive ovarian tumor, it usually follows
a benign clinical course. Very rare case reports of testicular lesions morphologically
resembling gynandroblastomas are in fact variants of juvenile granulose cell tumor,
or Sertoli cell tumor, or a combination of both.;