TYRO Protein Tyrosine Kinase Binding Protein

Preferred Label : TYRO Protein Tyrosine Kinase Binding Protein;

NCIt synonyms : DNAX-Activation Protein 12; KAR-Associated Protein; TYROBP; Killer-Activating Receptor-Associated Protein;

NCIt definition : TYRO protein tyrosine kinase-binding protein (113 aa, 12 kDa) is encoded by the human TYROBP gene. This protein is involved in the modulation of natural killer cell activity.;

NCIt note : Encoded by human TYROBP Gene, 113-aa 12-kDa (precursor) disulfide-linked homodimeric Tyr-phosphorylated TYRO Protein Tyrosine Kinase Binding Protein is a type I transmembrane polypeptide containing a cytoplasmic ITAM motif that may act as an activating signal transduction element in bone modeling, brain myelination, and inflammation. TYROBP associates with KIR family membrane glycoproteins without a cytoplasmic ITIM; KIR/TYROBP complexes promote cellular activation. TYROBP interacts with SIRPB1 and may bind TCR zeta chain-associated ZAP-70 kinase and SYK tyrosine kinase.;

Details

Origin ID

C30149;

UMLS CUI

C1336693;

OMIM relation
- Tyro protein tyrosine kinase-binding protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- TYROBP Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune System Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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