Lerisetron - CISMeF

Preferred Label : Lerisetron;

NCIt synonyms : 1-Phenyl-Methyl-2-Piperazinyl-1H-Benzimidazole Hydrochloride;

NCIt definition : The hydrochloride salt of a 2-piperazinylbenzimidazole-derivative serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of nausea and vomiting caused by cancer treatment. Lerisetron is a type of serotonin receptor antagonist and a type of antiemetic.;

UNII : Q36R82SXRG;

InChIKey : PWWDCRQZITYKDV-UHFFFAOYSA-N;

CAS number : 143257-98-1;

Molecule name : F-0930-RS2;

Chemical formula : C18H20N4;

Codes from synonyms : CDR0000044876;

Details

Origin ID

C30143;

UMLS CUI

C0758799;

Currated CISMeF NLP mapping
- lerisetron [MeSH concept]
- lerisetron [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lerisetron [MeSH Supplementary Concept]
- lerisetron [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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