Preferred Label : HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain;
NCIt synonyms : Major Histocompatibility Complex, Class II, DP Beta 1; HLA-DPB1; Major Histocompatibility Complex, Class II, DP Beta-1; HLA-DP Histocompatibility Type, Beta-1 Subunit; HLA-DP Histocompatibility Type Beta-1 Subunit;
NCIt definition : HLA class II histocompatibility antigen, DP(W4) beta chain (258 aa, 29 kDa) is encoded
by the human HLA-DPB1 gene. This protein plays a role in antigen presentation.;
NCIt note : Major Histocompatibility Complex, Class II, DP Beta 1 is encoded by the HLA-DPB1 gene.
HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules
are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both
anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains
6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic
tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain
the polymorphisms specifying the peptide binding specificities, resulting in up to
4 different molecules. (from LocusLink);
Origin ID : C30024;
UMLS CUI : C0122007;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
