Preferred Label : Anti-MUC-1 Monoclonal Antibody;
NCIt synonyms : Anti-MUC-1;
NCIt definition : A monoclonal antibody recognizing human mucin, a cell surface antigen encoded by the
MUC-1 gene. In normal tissue, mucin exists as heavily glycosylated form, while tumor-associated
mucin molecules are hypo-glycosylated. Hypo-glycosylation exposes the normally cryptic
tandem peptide repeats in cancer-associated mucin, thereby allows antigen-antibody
interaction with MUC-1 antibody. As a result, the MUC-1 antibody inhibits the initiation
of the immunosuppressive cascade triggered by mucin, including production and secretion
of prostaglandin E2 (PGE2), followed by VEGF induction and suppression of natural
killer cell, lymphokine-activated killer cell and cytotoxic T cell activity.;
Origin ID : C29983;
UMLS CUI : C1510931;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
