Triphenylethylene

Preferred Label : Triphenylethylene;

NCIt definition : the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology. Triphenylethylenes were initially developed for the treatment of estrogen-dependent breast cancers. Selective estrogen receptor modulators (SERMs) such as raloxifene and tamoxifen represent triphenylethylene derivatives that affect transcriptional regulation through modulation of specific alpha and beta estrogen receptors that are differentially expressed in various normal and neoplastic tissues. (NCI04);

UNII : S4ZLZ1K74B;

CAS number : 58-72-0;

NSC code : 17535;

Détails

Origin ID

C29863;

UMLS CUI

C0077252;

Currated CISMeF NLP mapping
- triphenylethylene [Substance BNPC]
- triphenylethylene [MeSH concept]
- triphenylethylene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- triphenylethylene [Substance BNPC]
- triphenylethylene [MeSH concept]
- triphenylethylene [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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