Sulindac Sulfide

Preferred Label : Sulindac Sulfide;

NCIt synonyms : (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid;

NCIt definition : The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04);

UNII : 6UVA8S2DEY;

CAS number : 49627-27-2;

Codes from synonyms : 09395;

Details

Origin ID

C29854;

UMLS CUI

C0075615;

Currated CISMeF NLP mapping
- 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1h-indene-3-acetic acid [Substance BNPC]
- Sulindac sulfide (substance) [SNOMED CT concept]
- sulindac sulfide [MeSH concept]
- sulindac sulfide [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1h-indene-3-acetic acid [Substance BNPC]
- Sulindac sulfide (substance) [SNOMED CT concept]
- sulindac sulfide [MeSH concept]
- sulindac sulfide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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