NCIt definition : A class of natural or synthetic sulfanilamide derivatives with antibacterial activity.
Sulfonamides are structural analogs of para-aminobenzoic acid (essential for microbial
folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA
for dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism
and ultimately DNA synthesis.;
Alternative definition : NCI-GLOSS: A type of antibiotic used to treat infection.;
NCI Metathesaurus CUI : CL557618;
Codes from synonyms : CDR0000367475; CDR0000367474;