Preferred Label : G Protein-Coupled Receptor 54;
Obsolete resource : true;
NCIt synonyms : G-Protein-Coupled Receptor GPR54; Metastin Receptor; G Protein-Coupled Receptor; G Protein-Coupled Receptor AXOR12; GPR54;
NCIt definition : Encoded by human GPR54 Gene, 395-aa 43-kDa G Protein-Coupled Receptor 54 is a Gq/11-coupled
receptor for endogenous KISS1 (Metastin), which appears to inhibit chemotaxis. (NCI); G Protein-Coupled Receptor 54, encoded by the GPR54 gene, is a G protein-coupled receptor.
The endogenous ligand of this protein is the KISS1 protein. The truncated form of
KISS1, metastin, inhibits chemotaxis and invasion of GPR54-transfected CHO cells in
vitro and attenuates pulmonary metastasis of GPR54-transfected B16-BL6 melanomas in
vivo. (from OMIM 604161);
Concept status : Retired_Concept;
GenBank Accession Number : NM_032551; AB051065;
Origin ID : C29671;
OMIM relation
- Semantic type(s)
