Preferred Label : Dihydrotestosterone;
NCIt synonyms : (5alpha,17beta)-17-Hydroxyandrostan-3-one;
NCIt related terms : DHT; androstanolone;
NCIt definition : The most potent androgen, required for sex development. Dihydrotestosterone is synthesized
from testosterone in the prostate gland, testes, hair follicles and adrenal glands
by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone,
which binds to and activates specific nuclear androgen receptors. After translocation
into the nucleus, the activated hormone-receptor complex binds to the androgen response
elements on the DNA and activates gene expressions that are required for sex development.
Dihydrotestosterone is responsible for the formation of male primary sex characteristics
and most male secondary sex characteristics during puberty, such as muscular growth,
facial and body hair growth, and deepening of the voice.;
Alternative definition : NCI-GLOSS: A hormone made from testosterone in the prostate, testes, and certain other
tissues. It is needed to develop and maintain male sex characteristics, such as facial
hair, deep voice, and muscle growth. High amounts of androstanolone may increase the
growth of prostate cancer and make it harder to treat.;
NCI Metathesaurus CUI : CL512804;
Codes from synonyms : CDR0000597127; CDR0000597135; CDR0000597120;
Origin ID : C29619;
UMLS CUI : C0038148;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
