TriGem - CISMeF

Preferred Label : TriGem;

NCIt definition : An anti-idiotype monoclonal antibody that mimics the disialoganglioside GD2, a cancer-associated antigen present on melanoma, small cell lung cancer, sarcoma, neuroblastoma and other malignancies. GD2 is a highly expressed glycosphingolipid by melanoma and other neuroectodermal tumors with only minimal expression on normal tissues. TriGem induces an immune response and can be the base for immunotherapy of melanoma and other cancers. (NCI04);

NCIt note : A monoclonal antibody directed against I17, proposed for treatment of advanced cancers expressing GD2 ganglioside;

Details

Origin ID

C29511;

UMLS CUI

C1259827;

Automatic exact mappings (from CISMeF team)
- trigeminal nerve [Radlex concept]
Currated CISMeF NLP mapping
- monoclonal antibody TriGem [MeSH concept]
- monoclonal antibody TriGem [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- monoclonal antibody TriGem [MeSH concept]
- monoclonal antibody TriGem [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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