NCIt definition : A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming
organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial
activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport
molecule that carries the building blocks of the peptidoglycan bacterial cell wall.
The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate
and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.;