NCIt definition : A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant
properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric
acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and
mesencephalic reticular system. This increases the frequency of chloride channel opening
events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization
and decreases neuronal excitability.;