" /> TGFa-PE38 Immunotoxin - CISMeF





Preferred Label : TGFa-PE38 Immunotoxin;

NCIt synonyms : TP-38;

NCIt related terms : TP-38 immunotoxin;

NCIt definition : A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of brain tumors. It combines a protein that binds to certain tumor cells with a bacterial toxin that kills tumor cells.;

Drug name : Cervene;

NSC code : 726586;

Codes from synonyms : CDR0000350249;

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15/05/2024


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