Tumor Infiltrating Lymphocytes-N2-Transduced

Preferred Label : Tumor Infiltrating Lymphocytes-N2-Transduced;

NCIt definition : A preparation of lymphocytes harvested from a patient and genetically modified ex vivo for use in gene therapy for the patient's cancer. Ex vivo, the lymphocytes are transduced with the N2 retroviral vector, which is modified to express a gene whose protein product either kills tumor cells or elicits specific anti-tumor immunity. Genetically modified lymphocytes are infused back into the patient from whom they were harvested, locate to the tumor site, and express the candidate protein that kills tumor cells or stimulates host anti-tumor immunity. (NCI04);

Details

Origin ID

C29478;

UMLS CUI

C1519682;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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