NCIt definition : A synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential
antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized
in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis
by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L
is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative
endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation,
and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule.;
Currated CISMeF NLP mapping