Preferred Label : Transferrin Receptor-Targeted Liposomal p53 cDNA;
NCIt synonyms : Synerlip p53; SGT-53;
NCIt definition : A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential
anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid
DNA encoding the tumor suppressor protein p53 packaged in membrane-like liposome capsules
that are complexed with anti-transferrin receptor single-chain antibody (TfRscFv).
Upon systemic administration, the anti-TfRscFv selectively binds to tumor cells expressing
transferrin receptors. The p53 plasmid is delivered into the nucleus and as a result,
p53 protein is produced in tumor cells that have altered p53 function. This results
in the restoration of normal cell growth control mechanisms as well as normal response
mechanisms to DNA damage.;
NCI Metathesaurus CUI : CL319865;
NSC code : 709399;
Origin ID : C29474;
UMLS CUI : C1515109;
Semantic type(s)
- concept_is_in_subset
