Preferred Label : DNA Minor Groove Binding Agent SG2000;
NCIt synonyms : Pyrrolobenzodiazepine Dimer; (11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one);
NCIt related terms : SJG-136;
NCIt definition : A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic
activity. Following intravenous administration, DNA minor groove binding agent SG2000
preferentially and covalently binds to purine-GATC-pyrimidine sequences, with the
imine/carbinolamine moieties of SG2000 binding to the N2 positions of guanines on
opposite strands of DNA. This induces interstrand cross-links and inhibits both DNA
replication and gene transcription, which lead to the inhibition of cell growth. With
a preference for binding to purine-GATC-pyrimidine sequences, SG2000 adducts do not
appear to be susceptible to p53-mediated DNA excision repair.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called DNA cross-linking agents.;
UNII : KT0ZQ64X1A;
CAS number : 232931-57-6;
Molecule name : SJG136; SG2000; BN2629; NSC 694501;
NSC code : 694501;
Codes from synonyms : CDR0000423254;
Origin ID : C29435;
UMLS CUI : C3827078;
Automatic exact mappings (from CISMeF team)
- 1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione) [MeSH Supplementary Concept]
- Currated CISMeF NLP mapping
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
