NCIt related terms : SANGIVAMYCIN MONOHYDROCHLORIDE;
NCIt definition : The salt of a deaza-adenosine antibiotic isolated from the bacterium Streptomyces
rimosus with potent cytotoxic properties. Sangivamycin inhibits protein kinase C (PKC),
a signaling mediator important for cell growth and differentiation. This agent may
also interfere with protein synthesis by inhibiting the formation of complexes essential
to the initiation of protein synthesis and DNA synthesis. (NCI04);