Pheniramine Maleate

Preferred Label : Pheniramine Maleate;

NCIt definition : The maleate salt form of pheniramine, an alkylamine derivative with antihistaminic and vasodilatory properties. Pheniramine maleate binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP (cGMP) levels, thereby inhibiting constriction of smooth muscle tissue, and decreased capillary permeability and histamine-activated allergic reactions.;

UNII : NYW905655B;

InChIKey : SSOXZAQUVINQSA-BTJKTKAUSA-N;

CAS number : 132-20-7;

Chemical formula : C16H20N2.C4H4O4;

Details

Origin ID

C29358;

UMLS CUI

C0887016;

Automatic exact mappings (from CISMeF team)
- pheniramine [Substance BNPC]
- pheniramine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pheniramine Maleate [MeSH concept]
- Pheniramine maleate (substance) [SNOMED CT concept]
- pheniramine hydrogen maleate [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Pheniramine [NCIt concept]
is_salt_form_of
- Pheniramine [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients