NCIt definition : A synthetic pyrethroid and neurotoxin. Permethrin affects the neuronal membrane by
blocking the movement of sodium ions from outside to inside the neuronal cell membrane
thereby disrupting the sodium channel current that regulates the polarization of the
membrane. This leads to delayed repolarization and subsequent paralysis of the nervous
system. Permethrin is used to eradicate parasites such as head lice, ticks and scabies
from humans and animals.;