Imidazole-Pyrazole

Preferred Label : Imidazole-Pyrazole;

NCIt synonyms : Imidazolepyrazole; 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole; IMPY; Pyrazole Imidazole;

NCIt related terms : PYRAZOLOIMIDAZOLE;

NCIt definition : A synthetic agent, also known as IMPY, with antineoplastic properties. IMPY inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides during DNA synthesis; this agent specifically binds the smaller, nonheme-iron subunit of the enzyme. (NCI04);

NCIt note : Inhibits the nonheme-iron subunit of ribonucleotide reductase;

UNII : MX6Z942BKY;

CAS number : 6714-29-0;

Molecule name : BRN 0742753;

NSC code : 51143;

Details

Origin ID

C29344;

UMLS CUI

C0045368;

Currated CISMeF NLP mapping
- 2,3-dihydro-1H-imidazo(1,2-b)pyrazole [MeSH concept]
- 2,3-dihydro-1H-imidazo(1,2-b)pyrazole [MeSH Supplementary Concept]
- 2,3-dihydro-1h-imidazo(1,2-b)pyrazole [Substance BNPC]
False automatic mappings
- (123I)IMPY [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2,3-dihydro-1H-imidazo(1,2-b)pyrazole [MeSH concept]
- 2,3-dihydro-1H-imidazo(1,2-b)pyrazole [MeSH Supplementary Concept]
- 2,3-dihydro-1h-imidazo(1,2-b)pyrazole [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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