Preferred Label : Nacolomab Tafenatox;
NCIt synonyms : C242Fab-SEA Immunotoxin;
NCIt definition : A recombinant fusion protein of the bacterial superantigen Staphylococcal enterotoxin
A (SEA) and the variable Fab fragment of the C242 monoclonal antibody. Upon administering
nacolomab tafenatox, the Fab fragment binds to Lewis antigen, a glycoprotein overexpressed
in human colon and pancreatic carcinoma cell surfaces, thereby directing PNU-214565
to the tumor target area and providing tumor specificity. Superantigen staphylococcal
enterotoxin A (SEA) promotes the crosslinking of T-cell receptor (TCR) Vb regions
with major histocompatibility complex (MHC) class II molecules on antigen presenting
cells, thereby enhancing cytotoxic T-lymphocyte activation, cytokine production and
tumor cell lysis.;
UNII : PRC47TA1NU;
CAS number : 150631-27-9;
Molecule name : PNU-214565;
Origin ID : C29328;
UMLS CUI : C1518802;
Semantic type(s)
- concept_is_in_subset
