Phosphoramide Mustard

Preferred Label : Phosphoramide Mustard;

NCIt definition : One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04);

ChEBI ID : CHEBI:8163;

Details

Origin ID

C29322;

UMLS CUI

C0070913;

Currated CISMeF NLP mapping
- phosphoramide mustards [MeSH Descriptor]
False automatic mappings
- phosphoramide mustard [MeSH concept]
- phosphoramide mustard [MeSH Supplementary Concept]
- phosphoramide mustards [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- phosphoramide mustard [MeSH concept]
- phosphoramide mustard [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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