Preferred Label : Neomycin/Polymyxin B/Bacitracin Zinc Ophthalmic Ointment;
NCIt synonyms : Neosporin Ophthalmic;
NCIt definition : A sterile combination preparationscontaining neomycin sulfate, polymyxin B sulfate
and bacitracin zinc, as the main active ingredients, for ophthalmic treatments. Polymyxin
B sulfate, a polypeptide produced by Bacillus polymyxa, binds to the negatively charged
phospholipids in the cell membrane, thereby altering the permeability of the bacterial
cytoplasmic membrane. Neomycin sulfate, an aminoglycoside antibiotic, irreversibly
binds to the bacterial 30S subunit proteins and 16S rRNA of ribosome, thereby causing
misreading and inhibiting protein synthesis which results in bactericidal effect.;
Drug name : Neosporin Ophthalmic;
Origin ID : C29287;
UMLS CUI : C3828836;
Manual NTBT mappings (CISMeF)
- Semantic type(s)
