Preferred Label : Neomycin/Polymyxin B/Bacitracin Zinc;
NCIt synonyms : Neosporin Cream;
NCIt definition : A combination preparation containing the aminoglycoside antibiotic neomycin sulfate,
the polypeptide antibiotic polymyxin B sulfate and bacitracin zinc, with topical antibacterial
activity. Polymyxin B sulfate, a polypeptide produced by Bacillus polymyxa, binds
to negatively charged phospholipids in the cell membrane, thereby altering the permeability
of the bacterial cytoplasmic membrane. Neomycin sulfate, an aminoglycoside antibiotic,
irreversibly binds to the bacterial 30S ribosomal subunit, thereby preventing mRNA
from binding to the 30S subunit, causes misreading and inhibits protein synthesis.;
Drug name : Neosporin Original;
Origin ID : C29286;
UMLS CUI : C4054410;
Manual BTNT mappings - CISMeF
- Semantic type(s)
- Validated automatic mappings to BTNT
