Nadolol - CISMeF

Preferred Label : Nadolol;

NCIt definition : A non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.;

UNII : FEN504330V;

InChIKey : VWPOSFSPZNDTMJ-UCWKZMIHSA-N;

CAS number : 42200-33-9;

Drug name : Corgard;

ChEBI ID : CHEBI:7444;

Codes from synonyms : 32068;

Details

Origin ID

C29280;

UMLS CUI

C0027302;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nadolol [ICD-11 Extension code]
- Nadolol [LOINC component]
- Nadolol (substance) [SNOMED CT concept]
- Product containing nadolol (medicinal product) [SNOMED CT concept]
- nadolol [ATC Code]
- nadolol [Substance BNPC]
- nadolol [MeSH concept]
- nadolol [MeSH Descriptor]
- nadolol [SNOMED Notion]
Validated automatic mappings to BTNT
- nadolol [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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