Mycophenolate - CISMeF

Preferred Label : Mycophenolate;

NCIt definition : The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04);

ChEBI ID : CHEBI:62932;

Details

Origin ID

C29272;

UMLS CUI

C0883242;

Automatic exact mappings (from CISMeF team)
- mycophenolate [EMDN type]
- mycophenolate [medical devices type]
See also inter- (CISMeF)
- Mycophenolic acid (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mycophenolate [LOINC component]
has_target
- Inosine Monophosphate Dehydrogenase [NCIt concept]

Keyword's position in hierarchy(ies) :

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